A UPIC audit is not a routine billing review. Unified Program Integrity Contractors (formerly ZPICs) work for CMS to find Medicare and Medicaid fraud, and their findings can lead to payment suspensions, large overpayment demands, and referrals to HHS-OIG or the DOJ.
Lowther | Walker’s UPIC audit lawyers, including former federal prosecutors, defend healthcare providers nationwide from the first records request through appeal.
Request your UPIC audit defense consultation now to review your response options.
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Call Us Today: (404) 496-4052
Investigation terminated; no prosecution. DOJ notified our client, the CEO of a major hospital network, that he was the target of a multi-million-dollar healthcare fraud investigation related to “Medicare upcoding” that the FBI and HHS-OIG […]
The FBI and the HHS-OIG investigated our client for Health Care Fraud based on the client’s submitting over $7 million in alleged false claims to Medicare. The Government indicted our client on Conspiracy to commit […]
HHS-OIG investigated our client for Healthcare Fraud and Aggravated Identity Theft based on the client’s alleged participation in a telemedicine kickback scheme that defrauded Medicare of approximately $30 million in reimbursements for not medically necessary […]
A private insurance company discovered that our client, a dentist, fraudulently billed it, various other insurance companies, and federal health care benefit programs for approximately $400,000 of services that our client did not provide. We […]
The Department of Justice’s Criminal Division, Fraud Section charged our client and nine other individuals in a $1.4 Billion health care fraud, wire fraud, and money laundering conspiracy (the largest health care fraud case that […]
Investigation terminated; no prosecution. DOJ notified our client, the CEO of a major hospital network, that he was the target of a multi-million-dollar healthcare fraud investigation related to “Medicare upcoding” that the FBI and HHS-OIG […]
The FBI and the HHS-OIG investigated our client for Health Care Fraud based on the client’s submitting over $7 million in alleged false claims to Medicare. The Government indicted our client on Conspiracy to commit […]
HHS-OIG investigated our client for Healthcare Fraud and Aggravated Identity Theft based on the client’s alleged participation in a telemedicine kickback scheme that defrauded Medicare of approximately $30 million in reimbursements for not medically necessary […]
A private insurance company discovered that our client, a dentist, fraudulently billed it, various other insurance companies, and federal health care benefit programs for approximately $400,000 of services that our client did not provide. We […]
The Department of Justice’s Criminal Division, Fraud Section charged our client and nine other individuals in a $1.4 Billion health care fraud, wire fraud, and money laundering conspiracy (the largest health care fraud case that […]
UPIC stands for Unified Program Integrity Contractor. These are private auditing and investigative companies contracted by the Centers for Medicare & Medicaid Services (CMS) to detect, investigate, and deter fraud, waste, and abuse across the Medicare and Medicaid programs.
If you’ve seen the term ZPIC (Zone Program Integrity Contractor), it refers to the same kind of audit. CMS replaced ZPICs with UPICs, combining Medicare and Medicaid program integrity work under one contractor in each region. The tactics are the same: data-driven targeting, records requests, site visits, payment suspensions, and referrals to law enforcement. Our ZPIC and UPIC audit lawyers handle both, including older ZPIC-era overpayments that are still under appeal.
Five UPIC jurisdictions cover the country, run by three contractors. The contractor’s name is on your letter, and it tells you who you’re dealing with and which Medicare Administrative Contractor (MAC) will handle your first appeal.
Contracts change. Confirm the current contractor on the CMS Review Contractor Directory.
Learn more about records requests during healthcare audits with our post on MAC audits vs. UPIC audits.
A payment suspension can cut off a practice’s Medicare revenue overnight, before any finding of wrongdoing. Under 42 C.F.R. § 405.372, a suspension based on reliable information of an overpayment is generally limited to 180 days, with possible extensions. A suspension based on a credible allegation of fraud can last much longer while the investigation continues.
UPIC overpayment findings are appealed through the standard five-level Medicare appeals process. The deadlines below are the outside limits. File faster to stop recoupment while you appeal.
Many of the strongest arguments are about the statistics. When a UPIC extrapolates from a sample, we test whether the sample and the universe of claims were defined correctly, whether the sampling followed the Medicare Program Integrity Manual, Chapter 8, and whether each “error” holds up on clinical review. Overturning a sample can wipe out most of an extrapolated demand. Our Medicare audit defense lawyers can guide the sampling error defense.
UPICs don’t prosecute, but they refer. Warning signs that an audit has turned into, or is running alongside, a criminal investigation:
At that point, the defense strategy changes completely. Lowther | Walker is a federal criminal defense firm, so the same team that handles the audit can protect you if it becomes a criminal case. If an agent has contacted you, read what to do when HHS-OIG contacts you.
If a UPIC suspects a “credible allegation of fraud,” they can request that CMS suspend your Medicare or Medicaid payments. Providers can be placed on up to 100% pre-payment review, meaning all newly submitted claims are frozen and meticulously scrutinized before any funds are released. This indefinite withholding of reimbursement often causes immediate operational cash flow disruptions before any liability has been formally adjudicated.
Post-payment audits scrutinize claims already paid to identify issues such as missing documentation, improper coding, or a lack of medical necessity. This process involves statistical sampling and extrapolation. UPIC auditors will review a small, localized sample of claims, calculate an error rate, and mathematically apply that percentage to the entire universe of a provider’s claims for that period. Because of extrapolation, a minor actual overpayment in the sample (e.g., $5,000) can instantly multiply into a catastrophic, multi-million-dollar recoupment demand.
UPIC investigations rarely happen by chance; they are proactively data-driven. Contractors use the CMS Fraud Prevention System and data analytics to identify statistical anomalies and “outliers”. Audits are triggered when a provider’s claims profile shows a high frequency of specific services compared to national peers, impossible billing hours, lengths of stay outside industry norms, or mismatched physician records. UPICs aggressively pursue leads generated by whistleblower complaints, beneficiary tips, and direct referrals from other agencies like the Office of Inspector General (OIG) and the FBI.
Unlike routine Medicare administrative reviews by MACs, UPIC audits are inherently investigative and frequently serve as precursors to formal federal healthcare fraud investigations. When a UPIC audit targets your healthcare practice or business, you face potential recoupment demands and referrals to the Department of Justice (DOJ), Office of Inspector General (OIG), or other federal law enforcement agencies.
Our UPIC audit lawyers include former federal prosecutors who know how UPIC findings become criminal referrals, because they’ve been on the other side of federal investigations. That changes how we respond to a records request, prepare staff for interviews, and frame an appeal.
With our deep understanding of federal healthcare enforcement mechanisms, our attorneys can help protect healthcare providers from immediate financial damage to their practice and potential criminal exposure.
Penalties for failing UPIC audits are significant. Auditors can refer healthcare providers for criminal prosecution, with ZPIC/UPIC audit penalties including:
UPICs can recommend that CMS suspend your Medicare payments. Overpayment-based suspensions are generally limited to 180 days, but fraud-based suspensions can last as long as the investigation does.
Contractors will use statistical sampling methodologies to transform findings from a small sample into massive monetary demands
After an audit, your practice may face 100% pre-payment review processes that limit cash flow
Criminal referrals are the most damaging consequence of a UPIC audit. Unified Program Integrity Contractors refer cases to OIG and the FBI for a formal federal investigation.
Federal penalties include exclusion from federal healthcare programs, including Medicare, after an audit finds suspicious payment activity and billing concerns.
By proactively contacting Lowther | Walker at any of the above stages, you can avoid consequences ranging from exclusion from your insurance network to criminal prosecution for healthcare fraud. We’ll work tirelessly to defend your practice and your future within the industry.
Our team has decades of healthcare compliance experience and has demonstrated our industry expertise while successfully defending a client in the highest-value healthcare fraud case the DOJ has ever prosecuted.
Providers face referral to state licensing boards when UPIC audits result in unfavorable outcomes that trigger further investigations.
When UPIC auditors target your practice, their sole focus is on identifying improper payments and potential fraud. The auditors have significant resources at their disposal. They can interview patients and search for indications of suspicious conduct and previous complaints.

Joshua Lowther and Murdoch Walker have built their reputations in healthcare defense by analyzing federal healthcare audits and fraud investigations and forming elegant defense strategies to halt the investigation’s progress. They know how UPIC audit findings can lead to criminal healthcare fraud cases and prepare clients through proactive analysis to stay ahead of prosecutors.
We engage directly with UPIC auditors from the earliest stages to establish control over the audit process.
We aggressively challenge improper sampling methodologies and extrapolation calculations that can artificially inflate overpayment demands.
Our team reviews all documentation before submission to identify vulnerabilities while ensuring compliance with audit requests.
We identify systemic weaknesses and implement robust compliance protocols to help prevent future enforcement actions.
Lowther | Walker’s UPIC audit defense services combine federal prosecution experience and healthcare regulatory expertise. Our advantages include:
Our prosecutorial background gives us unique insights into:
Lowther | Walker has built a reputation as one of the nation’s foremost healthcare fraud defense firms.
Our background work in helping clients navigate healthcare audits includes the following:
We’ve developed specialized intervention strategies to:
Our track record demonstrates consistent success in the following:
Our Healthcare representation experience includes intervening in UPIC audits for the following industries:
Last reviewed: October 10, 2026
Lowther | Walker’s experienced UPIC audit lawyers provide strategic defense during high-stakes audits and investigations, protecting your practice’s financial viability and professional reputation. Call our audit response team for guidance on:
Call Lowther | Walker at (404) 496-4052 and book a free, no-obligation consultation with an experienced audit attorney.
No-obligation. Fully confidential.
Call Us Today: (404) 496-4052
Standard billing practices may trigger aggressive ZPIC/UPIC enforcement actions. Healthcare providers should be particularly vigilant about:
Any Medicare-participating provider or supplier can be audited, including physicians, home health agencies, DME suppliers, hospices, and skilled nursing facilities.
Yes. Providers are required by federal law to comply with UPIC audit requests within a specific timeframe, usually 10–30 days.
Yes. UPICs have the authority to conduct unannounced site visits and interview staff as part of their investigations.
The timeline varies, but audits can take several months from the date of the initial request to the auditor’s final determination, especially if legal proceedings are involved.
Yes. UPIC overpayment findings go through the five-level Medicare appeals process, starting with redetermination by the MAC within 120 days. File within 30 days to stop recoupment while the appeal is pending. A UPIC audit lawyer can also challenge the sampling and extrapolation behind the demand.
Calendar the deadline, preserve all records, don’t contact patients about the audit, and speak with a UPIC audit lawyer before sending anything. The way you respond to the first request often shapes everything that follows.
Essentially, yes. CMS replaced Zone Program Integrity Contractors (ZPICs) with Unified Program Integrity Contractors (UPICs), which handle both Medicare and Medicaid. The defense strategies are the same, and older ZPIC overpayments may still be under appeal.